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Z. Naturforsch.
69c, 276 – 282
(2014)
doi:10.5560/ZNC.2014-0050
Elatumic Acid: A New Ursolic Acid Congener from Omphalocarpum elatum Miers (Sapotaceae)
1 Institute of Organic Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10–14, D-55128 Mainz, Germany. Fax: +49-6131-39-22338. E-mail:
opatz@uni-mainz.de
2 Department of Chemistry, Faculty of Science, University of Botswana, Block 237, Private Bag, 0022, Gaborone, Botswana
3 Department of Organic Chemistry, University of Yaoundé I, P. O. Box 812, Yaoundé, Cameroon. Fax: +237-22-235396. E-mail:
ngadjuibt@yahoo.fr
4 Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, D-55128 Mainz, Germany
5 Department of Biochemistry, University of Dschang, P. O. Box 67, Dschang, Cameroon
6 The African Academy of Sciences (AAS), P. O. Box 24916-00502, Nairobi, Kenya
7 Department of Pharmaceutical Sciences and Traditional Pharmacopeia, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, P. O. Box 8664, Yaoundé, Cameroon
*Authors for correspondence and reprint requests
Received March 6 / May 19, 2014 / published online August 6, 2014
A new triterpene diastereomer, 1, of the previously reported 3β,6β,19α-trihydroxy-urs-12-en-28-oic acid-24-carboxylic acid methyl ester was obtained from the stem bark of Omphalocarpum elatum Miers (Sapotaceae) along with α-amyrin acetate (2), spinasterol (3), spinasterol 3-O-β-d-glucopyranoside (4), and tormentic acid (5). The structures of the isolates were established on the basis of NMR and mass spectrometric data and by comparison with those previously reported in the literature. Compound 1 showed weak antibacterial activity against E. aerogenes ATCC13048 and EA3, K. pneumoniae ATCC29916, and P. aeruginosa; it also displayed moderate cytotoxicity against CCRF-CEM, CEM/ADR5000, and MDA-MB231 cells.
Key words: Omphalocarpum elatum, Triterpene, Cytotoxicity, Antimicrobial