|
Z. Naturforsch. 2014,
69b, 945 – 949
doi:10.5560/ZNB.2014-4116
Structure of Hormaomycin, a Naturally Occurring Cyclic
Octadepsipeptide, in the Crystal
1 Institut für Anorganische Chemie, Georg-August-Universität Göttingen, Tammannstrasse 4, 37077 Göttingen, Germany
2 Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37077 Göttingen, Germany
3 Institute of Radiochemistry and Experimental Molecular Imaging, University Clinic Cologne, Kerpener Strasse 62, 50937 Köln, Germany
Reprint requests to Prof. Dr. G. M. Sheldrick. Fax: +49-(0)551-39-33373. E-mail:
gsheldr@shelx.uni-ac.gwdg.de, or to Prof. Dr. A. de Meijere.
ameijer1@gwdg.de
Received May 30, 2014 / published online October 12, 2014
The structure of hormaomycin has been determined in two crystals grown under different conditions, i. e. in the absence and in the presence of magnesium chloride. In both crystals, the macrocyclic hexadepsipeptide assumes a rather flat conformation, and the dipeptide side chain resides in the same equatorial plane. This is a significant difference in comparison with the compact bent conformation of hormaomycin in solution, as previously determined by an extensive NMR study.
Key words: Crystal Structure, Hormaomycin, Macrocyclic Depsipeptide, X-Ray Diffraction