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Z. Naturforsch. 2014,
69b, 835 – 838
doi:10.5560/ZNB.2014-4093
Iridoid Glycosides from Lagotis alutacea
1 Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, 650500, P. R. China
2 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China
Reprint requests to Prof. Li-Juan Yang and Prof. Xiao-Dong Yang. Fax: +86-871-65910017. E-mail:
ljyyang@gmail.com (L. J. Yang),
xdyang@ynu.edu.cn (X. D. Yang)
Received April 25, 2014 / published online July 8, 2014
One new iridoid glycoside, lagotisoside F (1), was isolated from Lagotis alutacea, along with three known analogs, lagotisoside D (2), 6-O-α-l-(4′′-O-(E)-cinnamoyl) rhamnopyranosyl-catapol (3) and globularin (4). Their structures were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. Compounds 1–4 were evaluated for cytotoxic activity against HL-60, MCF-7, A549, SW480, and SMMC-7721 cells and exhibited no appreciable activity with IC50 values above 40 μm.
Key words: Logatis alutacea, Iridoid Glycosides, Lagotisoside F