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Z. Naturforsch. 2014,
69b, 721 – 727
doi:10.5560/ZNB.2014-3313
Catalyst-free, Solvent-promoted and Scalable Multicomponent Synthesis of 3-Aminoalkylated Indoles via a Mannich-type Reaction
School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China
Reprint requests to Dr. Zhi Guan or Dr. Yan-Hong He. Fax: +86-23-68254091. E-mail:
guanzhi@swu.edu.cn (Zhi Guan) or
heyh@swu.edu.cn (Yan-Hong He)
Received November 14, 2013 / published online June 7, 2014
A catalyst-free, solvent-promoted and scalable three-component Mannich-type reaction of indoles, aromatic aldehydes and secondary amines for the synthesis of 3-(1-dialkylaminoalkyl)-1H-indoles has been developed. The protocol provided a mild, simple and highly atom-economic alternative to prepare the title compounds, and the corresponding products could be obtained in good to excellent yields in most cases.
Key words: Solvent-promoted, Scalable, Multicomponent Synthesis, 3-Aminoalkylated Indoles
Supporting Material: