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Z. Naturforsch. 2014, 69b, 103 – 108
doi:10.5560/ZNB.2014-3218
Synthesis, Characterization and Antifungal Evaluation of Novel 2H-1,4-Benzoxazin-3(4H)-one Derivatives Linked with a 1,2,3-Triazole Moiety
Yuqin Jiang, Longfei Mao, Lin Zhu, Baoqi Ren, Wei Li, and Guiqing Xu
College of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, 453007, P. R. China
Reprint requests to Dr. Wei Li. Fax: +86-373-3329023. E-mail: 031172@htu.cn
Received August 2, 2013 / published online December 30, 2013
In order to obtain novel bioactive compounds with significant antifungal activities, a series of 2H-1,4-benzoxazin-3(4H)-one analogs linked with a 1,2,3-triazole moiety have been designed and synthesized via click reactions in a one-pot process at room temperature using CuCl as the catalyst. Their antifungal activities were tested against two plant-pathogenic fungi, Rhizoctonia cerealis (RC) and Colletotrichum capsici (CC). Statistical analysis showed that among the tested compounds in particular compound 3a exhibits a significant growth inhibitory activity against both RC and CC. All the synthesized compounds have been characterized by IR, HRMS and NMR experiments.
Key words: 1,2,3-Triazole, 2H-1,4-Benzoxazin-3(4H)-one, Rhizoctonia Cerealis, Colletotrichum Capsici
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