A B C
Z. Naturforsch. 2013, 68b, 391 – 396
doi:10.5560/ZNB.2013-3043
Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from Aromatic α-Bromoketones, Sodium Azide and Terminal Acetylenes via Cu/Cu(OTf)2-catalyzed Click Reaction under Microwave Irradiation
Azadeh Fazeli1, Hossein A. Oskooie1, Yahya S. Beheshtiha1, Majid M. Heravi1, Firouz Matloubi Moghaddam2, and Behzad Koushki Foroushani2
1 Department of Chemistry, School of Science, Alzahra University, P. O. Box 1993893973, Vanak, Tehran, I. R. Iran
2 Department of Chemistry, Sharif University of Technology, Tehran, I. R. Iran
Reprint requests to Prof. Dr. Majid M. Heravi. Fax: +98-2188047861. E-mail: mmh1331@yahoo.com
Received February 11, 2013 / published online April 19, 2013
Reaction of aromatic α-bromoketones, sodium azide and aromatic or aliphatic terminal acetylenes in the presence of Cu/Cu(OTf)2 following the classical method (aqueous acetonitrile at room temperature) and under microwave irradiation (H2O at 85 °C) leads to 1,4-disubstituted 1,2,3-triazoles as the final products after simple filtration.
Key words: Click Reaction, Copper/Copper Triflate, Cycloaddition, α-Bromoketones, 1,4-Disubstituted 1,2,3-Triazoles, Three-Component Reaction, Microwave Irradiation
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