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Z. Naturforsch. 2013, 68b, 362 – 366
doi:10.5560/ZNB.2013-2323
TiO2 Nanoparticles as an Efficient Catalyst for the One-pot Preparation of Tetrahydrobenzo[c]acridines in Aqueous Media
Shahrzad Abdolmohammadi, Mahdieh Mohammadnejad and Faezeh Shafaei
Department of Chemistry, Faculty of Science, East Tehran Branch, Islamic Azad University, P. O. Box 33955-163, Tehran, I. R. Iran
Reprint requests to Prof. Dr. Shahrzad Abdolmohammadi. Tel: +98-21-3359 4950. Fax: +98-21-3359 4332. E-mail: abdolmohamadi_sh@yahoo.com and s.abdolmohamadi@iauet.ac.ir
Received December 7, 2012; in revised form January 25, 2013 / published online April 19, 2013
A series of tetrahydrobenzo[c]acridinone derivatives have been prepared by a one-pot four-component reaction of 1-naphthol, aromatic aldehydes, dimedone, and ammonium acetate in aqueous media using a catalytic amount of titanium dioxide nanoparticles (TiO2 NPs). The advantages of this novel protocol include the excellent yields, operational simplicity, short reaction time, easy work-up, reusability of the catalyst and an environmentally friendly procedure.
Key words: Aqueous Media, Domino Knoevenagel-Michael Condensation, Tetrahydrobenzo[c]acridinones, TiO2 Nanoparticles
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