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Zeitschrift für Naturforschung B Contents Vol. 68b (2013)

Z. Naturforsch. 2013, 68b, 1253 – 1258

doi:10.5560/ZNB.2013-3129

Synthesis of Chiral Pyrimidin-2(1H)-ones from N-Carbamoyl Amino Acids

Ilya N. Egorov¹, Vladimir L. Rusinov^1,2 and Oleg N. Chupakhin^1,2

¹Institute of Chemistry and Technology, Ural Federal University, Mira St. 19, Ekaterinburg, 620 002, Russia

²Institute of Organic Synthesis of Russian Academy of Sciences, S. Kovalevskoy St. 22, Ekaterinburg, 620 041, Russia

Reprint requests to Dr. Ilya Egorov. Fax: +7(343)3740458. E-mail: i.n.egorov@gmail.com

Received May 1, 2013 / published online November 4, 2013

A series of previously unknown pyrimidin-2(1H)-ones containing chiral amino acid fragments was synthesized from 1,1,3,3-tetramethoxypropane and N-carbamoyl derivatives of amino acids under acidic conditions.

Key words: Heterocycles, Amino Acids, Condensation, Chirality, Pyrimidines

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