Z. Naturforsch. 2013, 68b, 1123 – 1128
BIOnic Liquids: Imidazolium-based Ionic Liquids with Antimicrobial Activity
Frank Postleb1, Danuta Stefanik2, Harald Seifert2, and Ralf Giernoth1
1 Universität zu Köln, Department für Chemie, Greinstr. 4, 50939 Köln, Germany
2 Universität zu Köln, Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Goldenfelsstr. 19–21, 50935 Köln, Germany
Reprint requests to Priv.-Doz. Dr. Ralf Giernoth. Fax: +49 221 47-05102. E-mail: ralf.giernoth@uni-koeln.de
Received June 7, 2013 / published online October 4, 2013
We have synthesized twelve new ionic liquids composed of an imidazolium-based cation in combination with an anion that shows antiobiotic or analgesic activity. These "BIOnic Liquids" have been tested towards their antibiotic activity in a standardized microbiological assay. A surprizingly large number of compounds shows high activity towards a set of bacteria which cannot be explained as simple cumulative effects. The general concept opens up completely new possibilities for the future development of pharmaceutically active compounds.
Key words: Ionic Liquids, Active Pharmaceutical Ingredients (API), Imidazolium Salts, Antibiotics, Antimicrobials, Analgesics
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