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Z. Naturforsch. 2013,
68b, 195 – 200
doi:10.5560/ZNB.2013-2237
Study of the Catalytic Activity of Zr(HPO4)2 in the Synthesis of Hexahydroquinoline Derivatives under Solvent-free Conditions
Department of Chemistry, Faculty of Science, East Tehran Branch, Islamic Azad University, P. O. Box 33955-163, Tehran, I. R. Iran
Reprint requests to Dr. Shahrzad Abdolmohammadi. Tel: +98-21-3359 4950. Fax: +98-21-3359 4332. E-mail:
abdolmohamadi_sh@yahoo.com or
sabdolmohamadi@qdiau.ac.ir
Received August 27, 2012 / published online February 20, 2013
2-Amino-7,7-dimethyl-5-oxo-1,4-diaryl-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile derivatives were synthesized by the one-pot four-component reaction of aromatic aldehydes, malononitrile, dimedone and arylamines in the presence of Zr(HPO4)2·H2O (α-ZrP) as an effective and recyclable solid acid catalyst, in high yields.
Key words: Acidic Salts, Green Method, Hexahydroquinoline-3-carbonitrile, Solvent-free, Zr(HPO4)2