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Z. Naturforsch. 2012,
67b, 421 – 425
doi:10.5560/ZNB.2011-0244
Isolation and Structure Determination of Three New Sesquiterpenoids from Achillea millefolium
1 Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060, Pakistan
2 H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
3 Department of Chemistry, Kohat University of Science and Technology, Kohat-26000, Pakistan
4 Center of Excellence for Advanced Materials Research and Chemistry Department, Faculty of Science, King Abdulaziz University, P. O. Box 80203, Jeddah 21589, Saudi Arabia
Reprint requests to Dr. Umar Farooq. E-mail:
umarf@ciit.net.pk
Received October 31, 2011; in revised form March 13, 2012 / published online May 31, 2012
Phytochemical investigation of the whole plant of Achillea millefolium led to the isolation of three new sesquiterpenes which were trivially named as sesquiterpene lactone-esters A and B (1 and 2), and sesquiterpene lactone-diol (3). The structures of these compounds were determined with the help of one- and two-dimensional (1D and 2D) NMR techniques including 1H NMR, 13C NMR, HMQC, HMBC, COSY, and NOESY experiments.
Key words: Achillea millefolium, Sesquiterpenes, Lactone-ester, Lactone-diol, Compositae