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Z. Naturforsch. 2012,
67b, 1314 – 1318
doi:10.5560/ZNB.2012-0184
Two New Stilbenoids from Cajanus cajan
1 Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, P. R. China
2 Graduate University of Chinese Academy of Sciences, Beijing 100049, P. R. China
3 Guangzhou University of Chinese Medicine, Guangzhou 510006, P. R. China
Reprint requests to Prof. S. X. Qiu. Fax: +86-20-37081190. E-mail:
sxqiu@scib.ac.cn;
huangriming@scib.ac.cn
Received July 5, 2012 / published online November 30, 2012
Two new stilbenoids cajanotone and cajanamide A (1–2), together with another six known ones (3–8) and four known dihydroflavones (9–12), have been isolated from the leaves of Cajanus cajan. Their structures were elucidated based on spectroscopic studies. A possible pathway to the new compounds 1 and 2 has been proposed. In vitro cytotoxicities of selected compounds against cancer cell lines HepG2, MCF-7 and A549 have been evaluated. Compounds 7 and 8 show strong cytotoxity against all the tested cell lines (with IC50 values in the range of 3.5–6.0 μM), and compounds 1 and 3 showed strong to moderate activity against the three cell lines.
Key words: Cajanus cajan, Pigeon Pea, Stilbenoid, Dihydroflavone, Cytotoxicity