A B C
Z. Naturforsch. 2012, 67b, 438 – 446
doi:10.5560/ZNB.2012-0028
Millifolides A–C. New 1,10-Seco-guaianolides from the Flowers of Achillea millefolium
Yong Li1,2, Zhi-Yu Ni1, Meng-Chu Zhu3, Kai Zhang4, Yi-Bing Wu4, Mei Dong1, Qing-Wen Shi1,4, Chang-Hong Huo4, Françoise Sauriol5, Hiromasa Kiyota6, Yu-Cheng Gu7, and Bin Cong1
1 Department of Forensic Medicine, Hebei Key Laboratory of Forensic Medicine, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, 050017, Hebei Province, P. R. China
2 Department of Thoracic Surgery, Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang 050011 Hebei Province, P. R. China
3 Laboratory Medical Science, School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, 212013, Jiangsu Province, China
4 Department of Medicinal Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, 050017, Hebei Province, P. R. China
5 Department of Chemistry, Queen's University, Kingston, Ontario K7L 3N6, Canada
6 Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiya, Aoba-ku, Sendai 981-8555, Japan
7 Syngenta Jealott's Hill International Research Centre, Berkshire, U. K.
Reprint requests to Q.-W. Shi. E-mail: shiqingwen@hebmu.edu.cn or H. Kiyota. E-mail: kiyota@biochem.tohoku.ac.jp or B. Cong. E-mail: hbydcongbin@126.com
Received January 27, 2012 / published online May 31, 2012
Ten 1,10-secoguaianolides were isolated from the flowers of Achillea millefolium. Their structures were determined on the basis of spectroscopic methods. Three of them (millifolides A–C) including two dimeric sesquiterpenoids exhibit new skeletons. Seco-tanapartholide A exhibited moderate cell growth inhibitory activity against the human cancer cell line MCF7WT (IC50 = 5.51 μm) in vitro.
Key words: Achillea millefolium, 1,10-Seco-guaianolides, Millifolides A to C, Structure Elucidation, Cell Growth Inhibition
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